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脑星形细胞瘤瘤周水肿区活检组织病理及超微结构研究 被引量:4

Study on pathological changes and ultrastructure of stereotactic poly-target biopsy specimens obtained from peritumoral edema area in astrocytomas
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摘要 目的 探讨星形细胞瘤瘤周脑水肿区的病理及发生水肿可能机制。方法 对15例星形细胞瘤瘤周水肿的宽度进行分级,共分三级:一级0-20mm、二级21-40mm、三级〉41mm。并对其立体定向多靶点活检组织进行光镜及电镜检查。结果 在星形细胞瘤瘤周水肿区内,发现有浸润的肿瘤细胞,肿瘤细胞形态与瘤体区标本的肿瘤细胞形态一致。随着肿瘤恶性度及瘤周水肿程度的增加,肿瘤细胞浸润的范围就更广。瘤体和瘤周水肿区毛细血管的分布和结构变化影响着瘤周水肿区的形态,瘤体毛细血管的明显异常,出现于大范围瘤周水肿区的病例。结论 脑星形细胞瘤瘤周水肿区是肿瘤浸润的范围,伴有脑水肿。瘤体及瘤周水肿区毛细血管超微结构均有不同程度的改变。 Objective To explore the nature and pathogenesis of peritumoral brain edema (PTBE) in astrocytomas. Methods PTBE was classified for three classes: first class 0-20mm, second class21-40mm,third class〉41mm. The pathological characteristics and ultrastructure in this area by stereotactic poly-target biopsy of 15 astrocytomases were studied with light and electron microscope. Results Infiltrating tumor cells were noted in peritumoral brain edema area in astrocytomas. The shape of these tumor cells was similar to the tumor bodys. It was found that the more malignant of tumor and serious of PTBE, the more wide of the tumor cell infiltrating. The distribution and structural changes of tumorous and peritumoral capillaries were found to affect the shape of peritumoral edema areas. In general marked abnormality of tumorous capillary ultrastucture ofen appeared in those cases with large peritumoral edema areas. Conclusion The peritumoral edema area of astrocytomas is extension of tumor cells accompanied by edema. The tumor body and PTBE all have a different change in capillary ultrastructure.
出处 《立体定向和功能性神经外科杂志》 2006年第2期90-92,共3页 Chinese Journal of Stereotactic and Functional Neurosurgery
关键词 星形细胞瘤 瘤周脑水肿 立体定向活检 超微结构 Astrocytomas Peritumoral brain edema Stereotactic biopsy Ultrastructure
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