摘要
目的 探讨星形细胞瘤MRI表现与PCNA表达的关系。方法 收集手术病理证实的脑星形细胞瘤42 例,分析其MRI表现。采用免疫组化方法标记肿瘤PCNA。对照PCNA表达程度与MRI表现的关系。结果 星形细胞瘤PC NA表达强弱与病理级别相关,星形细胞瘤信号均匀性、边界清楚与否、瘤周水肿程度及增强程度与PCNA表达之间有统计学差异,但肿瘤部位及大小与PCNA表达没有相关性。结论 星形细胞瘤MRI表现,特别是脑水肿、增强程度、肿瘤边界等征象,在一定程度上可以反映PCNA表达强弱。
Objective To study correlation of MRI features with PCNA expression in brain astrocytoma. Methods MRI findings in 42 patients with surgically and pathologically proved astrocytoma were retrospectively analyzed. PCNA was stained with immuno-histochemical technique, and PCNA expression levels were compared with MRI features. Results PCNA expression levels correlated well with pathological grade of brain astrocytoma ( P <0.01). MRI signs such as heterogeneous signal intensity, ill-defined margin, the extent of peri-tumor edema and the degree of contrast enhancement had statistical correlation with PCNA expression levels. But the size and the location of lesions showed no obvious correlation with PCNA expression levels.Conclusion MRI features of brain astrocytoma, especially the extent of peri-tumor edema, the degree of contrast enhancement and ill-defined margin can reflect the level of PCNA to some extent.
出处
《中国医学影像技术》
CSCD
北大核心
2005年第4期541-543,共3页
Chinese Journal of Medical Imaging Technology
关键词
星形细胞瘤
磁共振成像
增殖细胞核抗原
Astrocytoma
Magnetic resonance imaging
Proliferating cell nuclear antigen
