摘要
目的:制备葛根素／β-环糊精包合物,并考察其溶解度。方法:用捏合法制备葛根素／β-环糊精包合物,采用紫外光谱法和相溶解度法研究包合过程,差示扫描量热分析、X-衍射、1H-NMR验证包合物,并测定了包合物的溶解度。结果:葛根素与β-环糊精可形成1:1(物质的量比)的稳定包合物,包合常数398 L·mol-1。37℃下包合物使葛根素的溶解度增加5．55倍。结论:β-环糊精对葛根素增溶作用明显,适用于葛根素口服制剂的改进。
Objective：To investigate the preparation and solubility of the inclusion complex of puerarin and β-cyclodextrin. Methods： The inclusion complex of puerarin and β-cyclodextrin was prepared using a kneading technique. The inclusion process was monitored by ultraviolet spectroscopy and phase solubility-test. The inclusion complex was validated by DTA, XRD and ^1H-NMR. The solubility of the complex was measured using phase solubility analysis. Results ：Puerarin formed an optimal inclusion complex with/3-cyclodextrin at a molar ratio of 1 ： 1, which had an equilibrium constant of 398 L· mol^-1 The solubility of puerarin was increased by 5.55 times in presence of one molar of β-cyclodextrin at 37℃. Conclusion：β-cyclodextrin seemed an ideal soluble enhancer of oral puerarin preparations.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2006年第7期528-532,共5页
Chinese Journal of New Drugs
关键词
葛根素
Β-环糊精
包合物
包合常数
溶解度
puerarin
β-cyclodextrin
inclusion complex
equilibrium constant
solubility
