摘要
目的:通过测定脑梗死患者急性期,恢复期血清和脑脊液S-100B蛋白含量动态变化,探讨其在脑梗死发病中的临床意义。方法:60例脑梗死住院患者(梗死组),将发病72 h和7、21d的脑脊液及静脉血测定血清和脑脊液中S-100B蛋白含量,并分别与正常组比较。结果:梗死组患者发病72 h和7 d时血清和脑脊液S-100B蛋白显著高于21 d患者和正常组(P<0.01);血清和脑脊液S-100B蛋白含量与梗死体积及神经功能缺损程度均呈正相关(P<0.01);脑脊液S-100B蛋白含量与年龄正相关,血清S-100B蛋白含量与年龄无关。结论:血清或脑脊液中的S-100B蛋白浓度可反映神经胶质细胞的损害程度,对判断病情程度,评估预后和调整治疗方案有重要意义。
Objective： To investigate the change of S-100B protein in serum and cerebrospinal fluid （CSF） of the patients with acute cerebral infarction in acute and recovery stages in order to explore its implication in the pathogenesis of cerebral infarction. Methods： Sixty patients with cerebral infarction in experimental group and 32 in control group were measured for S-100B protein in CSF and serum at 72 h, 7 days and 21 days after cerebral infarction by enzyme linked immunosorbent assay. Results： The level of S 100B protein in serum and CSF of the patients with acute cere bral infarction （72 h and 7 days experimental group） was higher than in the 21 day experimental group and control group （P〈0.01）. The level of S-100B protein in serum and CSF was positively correlated with the infarct volume and neurologic deficits in cerebral infarction （both P〈 0. 01 ）. The level of S-100B in CSF was related with ages, while serum S-100B protein level was not with ages. Conclusion： The concentration of S-100B protein in serum and CSF of the patients with acute cerebral infarction could imply the lesions of nueroglial cells.
出处
《中国康复》
2006年第2期89-90,92,共3页
Chinese Journal of Rehabilitation
