摘要
目的观察脂肪乳剂对严重烧伤病人中的蛋白置换作用。方法选择2002年3月-2005年9月间非手术严重烧伤病人例共67例,烧伤面积在48％～75％,随机分为中链脂肪乳治疗组(简称治疗组)31例和对照组36例,其中,治疗组于伤后第4天给予20％中链脂肪乳,500 ml/d,8～10 h缓慢静脉输入,连续10 d;对照组给予平衡盐500 ml静脉输入,其余治疗两组保持一致。于伤后第1、7及14天检测静脉血总蛋白、白蛋白、总胆固醇、甘油三酯含量。结果两组病人在伤后第1天静脉血总蛋白、白蛋白、总胆固醇、甘油三酯含量均在正常值范围内。伤后第7天总蛋白、总胆固醇和甘油三酯含量在正常值范围之内;而两组血浆白蛋白含量均低于正常值,但两组无显著性差异[(32±4．83)g／L vs (31±5．04)g／L, P>0．05]。伤后第14天,静脉血总胆固醇、甘油三酯含量均降低,但两组无统计学差异[(1．08±0．61)μmmol／L vs (0．97± 0．42)μmmol／L,前者为治疗组,后者为对照组,下同,P>0．05],而总蛋白及白蛋白含量均低于正常值,其中对照组的白蛋白含量降低更为明显,与治疗组有显著性差异[(28±6．46)g／L vs (23±7．03)g/L,P<0．01]。结论脂肪乳剂有较好的“蛋白消耗置换”作用,可以减轻血浆白蛋白的消耗,是严重烧伤病人较理想的能源物质。
Objective To investigate the effect of intralipid on, protein consumption in severe burned patients. Methods Sixty-seven nonoperative patients with severe burns were divided into Intralipid treatment group and non-intralipid treatment group （control group）, and the former was treated with 20% intralipid （500 ml once a day） from postbum day 4 for 10 consecutive days. Venous blood samples were collected from these patients for testing total protein, albumin, total cholesterol and triglyceride on postburn days 1, 7 and 14, respectively. Results The levels of total protein, albumin, total cholesterol and triglyceride were within normal range on postburn day 1 in both groups, and only the albumin level was lowered in the groups on day 7 but at comparable magnitudes （32±4.83 vs 31±5.04 g/L,P〉0.05）. In contrast, the levels of total protein, albumin, total cholesterol and triglyceride were below the normal range on postburn day 14 in both groups, but intralipid treatment group showed more albumin loss than the control group （28±6.46 vs 23±7.03 g/L, P〈0.01）. Conclusion Intralipid （20%） provides good energy source to ameliorate albumin loss in severe burned patients.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2006年第4期500-501,共2页
Journal of Southern Medical University
基金
广州市科技计划资助项目(2003Z3-E0371)~~
