摘要
目的探讨脑梗死患者血中D-二聚体(D-Dimer)、超敏C-反应蛋白(hs-CRP)、一氧化氮(NO)含量变化与脑梗死发生的关系。方法分别采用ELISA法、免疫散射比浊法和硝酸还原酶法测定D-Dimer、hs-CRP和NO含量。结果脑梗死组D-Dimer和hs-CRP含量明显高于对照组(P<0.01);脑梗死NO含量明显低于对照组(P<0.01);NO与D-Dimer(r=-0.50),P<0.05和hs-CRP(r=-0.68,P<0.01)含量经统计学处理呈负相关;D-Dimer和hs-CRP含量经统计学处理呈正相关(r=0.64,P<0.01);而且脑梗死面积大组D-Dimer和hs-CRP含量明显高于面积小组(P<0.01)。结论血中D-二聚体、超敏C-反应蛋白、一氧化氮含量与脑梗死的发生及发展有密切关系。
Objective To study the correlation between the levels of D-Dimer, high sensitive C-reaction and nitrogen monoxide in serum of patients with cerebral infarction. Methods The level s of D-Dimer, hs-CRP and NO were detected respectively in 48 patients with cerebral infarction and 48 healthy persons by ELISA,immunoturbidimitric assay and nitrate reducase method. Results Compared with healthy persons, the levels of D-Dimer and hs-CRP in serum of patients with cerebral infarction were significantly higher （P 〈 0.01）, and the level of NO in serum of patients with cerebral infarction were significantly lower （ P 〈 0.01 ）. The level of NO was negatively correlated with that of D-Dimer and hs-CRP; The level of D- Dimer ＇was positively correlated with that of hs-CRP; The levels of D-Dimer and hs-CRP in serum of patients with big infarction area were significantly higher than that patients with small infarction area.Conclusion The levels of D-Dimer,hs-CRP and NO closely related to the existence and development of cerebral infarction.
出处
《中国实验诊断学》
2006年第4期334-336,共3页
Chinese Journal of Laboratory Diagnosis
关键词
脑梗死
D-二聚体
超敏-CRP
一氧化氮
cerebral infarction
D- Dimer
high sensitive C-reaction
nitrogen monoxide
