摘要
目的探讨粘蛋白MUC2,VEGF在胃癌中的表达及其与胃癌病理特征之间的关系。方法采用免疫组化SP法检测10例正常胃黏膜及49例胃癌组织中MUC2,VEGF的表达。结果MUC2,VEGF在正常胃黏膜中没有表达;MUC2在胃癌中的表达率为73.5%;VEGF在胃癌中的表达率为75.5%.MUC2与胃癌的病理组织分型密切相关,高中分化腺癌、低分化腺癌、黏液腺癌的阳性率分别为81.0%,52.6%,100%,差异有显著性(P<0.05),黏液腺癌的强阳性表达率为77.8%,与另外两种组织学分型之间差异有非常显著性(P<0.01)。VEGF与胃癌的浸润深度、有无淋巴结转移、TNM分期密切相关(P值分别为0.048,0.000,0.011),且在有淋巴结转移的患者中的阳性与强阳性表达与无淋巴结转移的患者之间的差异有非常显著性(P<0.01)。结论VEGF,MUC2是胃癌发生发展中的重要因子。MUC2在不同的组织学类型的胃癌中表达不同,黏液腺癌中表达最强。VEGF在胃癌的侵袭转移中起重要作用,尤其与胃癌的淋巴结转移密切相关。MUC2,VEGF的联合表达与胃癌的浸润转移密切相关。
Objective To explore the expression of mocins（ MUC2 ） and vascular endothelial growth factor （YEGF） in primary gastric carcinoma and the relationship between them. Methods The MUC2 and VEGF were detected by immunohistoehemistry. All specimens including 49 gastric careinoma, In contrast to 10 normal gastric mucosas as eanctrol. Results The positive rate of the MUC2 in gastric carcinoma was 73.5 %, the positive rate of the VEGF were 75.5 % respectively. Both MUC2 and VEGF were not detected in normal gastric, mucosa. The expressian of MUC2 was significantly associated with types of cancers and had strongest expression in mutinous carcinomas（ P 〈 0. 05）. VEGF was up regulated from normal gastric mucosa to gastric cancer, and its expression significantly relatian to the depth of invasion, TNM staging and lymph nodes metastasis （ P = 0. 048,0.000,0.011, respectively） . Conclusion Both MUC2 and VEGF are important factors in the formation of gastric eareinoma,good marker of its invasion and metastasis.
出处
《潍坊医学院学报》
2006年第2期94-96,共3页
Acta Academiae Medicinae Weifang
