摘要
本研究对６８例氯丁二烯（ＣＢＤ）接触工人和４９例健康人进行了调查。结果显示，ＣＢＤ接触组血清中甘胆酸（ＣＧ）含量明显升高，而血清中丙氨酸转氨酶、硫酸锌浊度试验和麝香草酚浊度试验无明显改变；全血谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）活性和血清铜蓝蛋白（ＣＰ）含量明显降低，这与动物实验结果基本一致，即ＣＢＤ在体内生成的活性中间物可导致氧化性损害。血清ＣＧ含量、全血ＧＳＨ—ｐｘ活性及血清ＣＰ可能是接触ＣＢＤ所致不良健康效应的生物标记。
The biomarkers of adverse health effects of exposure to 2-choro-1,3-butadiene(CBD)were studied both in 68 CBD workers and in 49 health volunteers.The results showed that the level of serum cholyglycine(CG)in exposure group was markedly higher than that in control group,with no differences in serum alanine aminotransferase(ALT)level,zinc sulfate turbidity test(ZnTT)and thymol turbidity test(TTT).Meanwhile the activity of erythrocytic glutathione peroxidase(GSH-Px)and content of serum ceruloplasmin(CP)in exposed group were markedly lower than that incontrol group.The results from present study are similar to that from previous animal experiments conducted in our laboratory.It suggests that CBD may induce oxidative damage.and serum ,and erythrocytic GSH-Px may be the biomarkers of adverse health effects for exposure to CBD.
出处
《中国工业医学杂志》
CAS
1996年第2期79-80,共2页
Chinese Journal of Industrial Medicine
关键词
氯丁二烯
肝损害
生物标记
chloro-1,3-butadiene,biomarkers,adverse health effect
