摘要
为研究接铬工人的生物监测指标，利用简便、快速、经济、敏感的１２５Ｉ后标记法检测某合金厂１８７名接铬工人和５７名某水电站工人（对照）的血白细胞ＤＮＡ－蛋白质交联物（ＤＰＣ）。结果表明，接触组ＤＰＣ水平明显高于对照组，接触６价铬者又明显高于接触３价铬者和对照组，而接触３价铬者和对照组ＤＰＣ水平差异无显著性。未发现性别、年龄、工龄、吸烟、饮酒等对ＤＰＣ水平有影响，提示ＤＰＣ能很好地反映铬对人体的遗传毒效应。
DNA-proteincroslinks(DPC)intheperipheralwhitebloodcelsof187workersexposedtochromi-umand57controlsweredetectedwith125Ipostlabelingassay,whichisasimple,rapid,inexpensiveandsensitivemethod.TheresultsshowedthatthecontentofDPCinworkersexposedtochromiumwassignificantlyhigherthanthatincontrols,andtheworkersexposedtochromiumwithavalenceofⅥhigherthanthatofⅢandcontrol.Thedif-ferenceofDPClevelbetweencontrolandtheworkersexposedtochromiumⅢwasnotsignificant.Nomarkeddifer-enceofDPCformationwasfoundamongsex,age,durationofwork,smoking,andalcoholdrinkingstatus.Itissug-gestedthatDPCcanbeconsideredasabiomarkertoreflectthegenotoxicefectsinducedbychromium.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1996年第1期7-9,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
