摘要
目的:研究趋化因子配体18(CCL 18)在胃癌中的表达,为进一步探讨其在胃癌演进和转移中的作用奠定基础。方法:采用酶联免疫吸附试验法(EL ISA)检测45例胃癌患者及30例健康对照组外周血中CCL 18的浓度,同时应用免疫组化检测45例肿瘤组织CCL 18趋化因子的表达情况。结果:胃癌患者外周血中的浓度显著高于对照组(P<0.01)。在胃癌组织中,CCL 18表达阳性率明显高于正常胃粘膜组织(P<0.001)。结论:胃癌组织中存在着CCL 18高表达,外周血浓度明显升高,提示CCL 18可能进一步开发为胃癌的一种生物学标志物。
Objective： To analyze the expression of Chemokine CC-motif Ligand 18 （CCL18） in gastric cancer. Methods： The levels of serum CCL18 in 45 patients with gastric cancer were analyzed by ELISA method. Immunohistochemistry assay was used to detect the expression of CCL18 in 45 gastric cancer tissues. Results： The levels of serum CCL18 in 45 patients with gastric cancer were significantly increased, compared with control groups （P 〈 0.01）. The expression of CCL18 were significantly increased in tissues of gastric cancer （P 〈 0.001）. Conclusion： Chemokine CC-motif Ligand 18 is expressed in gastric cancer tissues with higher serum level. This study suggests CCL18 as novel candidate of gastric cancer marker.
出处
《华夏医学》
CAS
2006年第1期6-8,共3页
Acta Medicinae Sinica
基金
深圳市科技局计划项目(JH200505300473B)
关键词
胃肿瘤
趋化因子
标志物
stomach neoplasms
chemokine
marker
