摘要
目的:探讨环氧化酶-2(Cox-2)基因在鼻咽癌(nasopharyngealcarcinoma,NPC)组织中的表达及其临床意义。方法:采用免疫组织化学技术检测86例NPC组织中Cox-2蛋白表达情况,所有病例随访达5年以上,分析其与临床病理及预后的关系。结果:Cox-2在NPC组织中阳性表达率为73·3%(63/86),与原发灶范围(P<0.05)、颈淋巴结转移(P<0.05)和肿瘤分级均密切相关,P<0·05,且与预后有关,生存期≤5年组Cox-2蛋白表达阳性率(84.4%)显著高于生存期>5年组(61.0%),P<0·05。结论:Cox-2在NPC组织中高表达,可作为判断预后的一种有用指标;Cox-2选择性抑制剂有望成为NPC防治的新靶点。
OBJECTIVE： To investigate the expression of cyclooxygenase-2 （ Cox-2 ） gene in nasopharyngeal carcinoma （NPC） and its correlation with clinicopathological features.METHODS： The expression of Cox-2 protein was detected with immunohistochemical methods in eighty-six NPC patients occured over 5 years. RESULTS.. The overexpression rate of Cox-2 in NPC was 73.3% （63/86） and it was correlated to the primary tumor size, lymph node metastasis, pathological grade, and distant metastssis（P〈0.05）. The positive rate of Cox-2 expression was 84.4% in patients who survived ≤5 years, which was higher than that 61.0% in patients who survived 〉5 years,P〈0.05.CONCLUSIONS： Cox-2 is highly expressed in NPC and strongly correlated with prognosis. Cox-2 inhibitor may be a promising target for tumor chemoprevention and treatment,
出处
《中华肿瘤防治杂志》
CAS
2006年第6期430-432,459,共4页
Chinese Journal of Cancer Prevention and Treatment
