摘要
目的：探讨贲门癌患者外周血淋巴细胞能否代替肿瘤细胞进行体外药敏试验，以指导不能行肿瘤细胞化疗药敏检测患者的临床化疗。方法：采用MTT法体外药敏试验，检测28例贲门癌患者外周血淋巴细胞和肿瘤细胞对9种临床常用抗癌药物的敏感性。结果：贲门癌患者外周血淋巴细胞与其肿瘤细胞的体外药敏试验对9种抗癌药物的敏感性差异无统计学意义，P值为0．500～1．000。两种细胞药敏试验对5-FU、DDP、CBP、MTX、Vp-16、CTX和THP敏感，对ADM不敏感。结论：贲门癌患者外周血淋巴细胞与其肿瘤细胞对化疗药物的敏感性具有良好的正相关性，外周血淋巴细胞化疗药敏检测对临床选择化疗药物具有重要参考价值。
OBJECTIVE： To investigate whether chemosensitivity by peripheral blood lymphocyte of cardiac carcinoma could take the place of chemosensitivity test in vitro by tumor cells. METHODS： MTT method was used to test the sensitivity of the peripheral blood lymphocyte and the tumor cells of 28 patients with cardiac carcinoma to 9 kinds of anticancer drugs. RESULTS：There was no significant difference in the rate of sensitivity to the abovementioned drugs between the peripheral blood lymphocyte and cardiac carcinoma cells. The P values were 0. 500-- 1. 000. The two cells were sensitive to chemotherapeutic drugs of 5-FU, DDP, CBP, MTX,Vp-16, CTX, and THP, but not sensitive to ADM. CONCLUSIONS： There was a positive correlation in the sensitivity to the above-mentioned drugs between peripheral blood lymphocyte and tumor cells of cardiac carcinoma. The chemosensitivity test of the peripheral blood lymphocyte can become valuable for selecting anticancer drugs for chemotherapy.
出处
《中华肿瘤防治杂志》
CAS
2006年第5期351-353,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
抗肿瘤药/药理学
胃肿瘤/病理学
淋巴细胞亚群
贲门
antineoplastic agents/pharmacology
stomach neoplasms/pathology
lymphocyte subsets
cardia
