摘要
目的 观察局部晚期鼻咽癌患者单纯放疗和放疗联合化疗的疗效和毒副作用。方法 将89例Ⅲ～Ⅳa期鼻咽癌患者随机分为两组，研究组（A组）45例，放疗同期应用化疗（化疗方案：顺铂20mg／a，静脉滴注，第1～5天；氟脲嘧啶500mg／a，静脉滴注，第1～5天；亚叶酸钙0．2g／a，静脉滴注，第1～5天）；对照组（B组）44例，单纯放疗。结果 研究组和对照组的完全缓解率、颈淋巴结残留率分别为82．22％、75．00％和11．54％、26．09％，差异无统计学意义，P〉0．05。2年及5年生存率分别为53．33％、47．73％和26．67％、20．45％，差异无统计学意义，P〉0．05。两组毒副作用差异有统汁学意义，研究组胃肠道反应、骨髓抑制比对照组明显增大，P〈0．05。结论 放疗联合化疗对局部晚期鼻咽癌的疗效提高不能完全肯定。
Objective To observe the efficacy and side effects of pure radiotherapy and radiotherapy combined with chemotherapy to patients with locally advanced nasopharyngeal carcinoma （LA- NPC）. Method Eight - nine patients with Ⅲ - Ⅳa NPC were randomized into two groups. Fortyfive patients received radiotherapy combined with chemotherapy as study group（A）, and 44 patients received radiotherapy alone as control group（B）. The chemotherapy regimen consisted of cisplatin（DDP） 20 mg/d given in i. v. on day 1 - 5, and fluomuracil（5 - FU） 500 mg/d given in i. v. on day 1 - 5, CF 0.2 g/d given in i. v. on Day 1 - 5. Results The relief rate in group A were 82.22% in pure group and 75.00% in control group, respectively, P 〉0.05. The tumor remaining rates were 11.54%, 26.09% ,respectively P〉0.05. The two - year survival rates were 53.33% and 47.73%, five - year survival rates were 26.67 % and 20.45 %, P 〉0.05 respectively. The side effects including gastrointestinal response and bone marrow depression in union group was markedly higher than those in pure group, P〈 0.05. Conclusion Radiotherapy combined with chemotherapy may not increase the effect of LA - NPC of patients compared with pure radiotherapy.
出处
《中国医师进修杂志》
2006年第1期15-17,共3页
Chinese Journal of Postgraduates of Medicine
关键词
鼻咽肿瘤/放射疗法
鼻咽肿瘤/化学疗法
预后
Nasopharyngel neoplasms/radiotherapy
Nasopharyngel neoplasms/chemotherapy
Prognosis
