摘要
转录激活蛋白1参与调控多种基因的表达,导致机体产生一系列生理病理变化,是细胞信号转导的枢纽。人类的正常妊娠从孕卵着床开始到分娩结束,是一个复杂而精密的调控过程。经过对核转录因子激活蛋白1的结构特征及生理活性及其在妊娠、分娩中作用的相关研究,得出核转录因子激活蛋白1调控妊娠、分娩的不同基因并发挥许多相应的生物学功能,为研究妊娠维持与分娩发动的机理提供理论依据。
AP-1 participates in regulation of expression of different genes and this results in a series of physiopathological changes in body. AP-1 is a hub of signaling pathways in cells, From the embryo implantation to birth of the fetus, human normal pregnancy experiences complicated and precise modulation process. From the relating researches on structural feature, physiological activity of AP-1 and its role in human pregnancy and labour, we concluded that AP-1 regulates and control different target genes and exerts distinct relevant biological functions during pregnancy and labor. This conclusiorn provide theoretical basis for research on pregnancy maintenance and labour initiation.
出处
《中国妇幼健康研究》
2006年第1期24-26,共3页
Chinese Journal of Woman and Child Health Research
