摘要
高纤维蛋白原血症是心、脑血管疾病的一个独立危险因素,纤维蛋白原水平与颈动脉粥样硬化的严重程度有关。纤维蛋白原(fibrinogen Fg)即凝血因子Ⅰ,是由肝细胞合成、分泌的一种糖基化蛋白,在凝血、血小板聚集、纤溶活性调节,动脉粥样硬化的发生、发展过程中起着重要的作用,纤维蛋白原及代谢产物通过多种途径导致和加重颈动脉粥样硬化,如:纤维蛋白原代谢产物(尤其D/D二聚体)沉积在动脉管壁;增加内皮细胞的通透性,降低内皮细胞表面纤溶活性;刺激平滑肌细胞(smc)使其增殖等。
Hyperfibfinogenemia is an independent risk factor of cardiovascular disease and ischemic cerebravascular disease. The level of fibrinngen is related to the severity of carotid artery scleratheroma. Fibrinogen （Fg） （called coagulation factor 1 ）is glucasyl-protein synthesized and secreted by liver cells, which play an important role irt coagulation platelet aggregation, regulation of fibrinolytic activity and development of atherosclerosis. Fibrinogen and its metabolic products can canse the oocurance and exacerbation of carotid artery scleratheroma in many aspects including Fibrinoogen dcgration products （special Fragment D/D-direct） laying on aterial wall, improving permeability of the cndothelium, decreasing fibrinolytic activity on the sudaee of eedothelium cells, stimulating proliferation of smooth muscle cells and so on.
出处
《医学综述》
2006年第7期441-443,共3页
Medical Recapitulate
