摘要
采用溶剂挥发法制得氟尿嘧啶聚乳酸微球。以载药量及包封率为评价指标,通过正交设计优化处方。制品外观圆整,表面有细小孔隙,平均粒径为80μm,平均载药量10％,包封率为84％,体外释药用双相动力学方程拟合效果较好, 释药机理为溶蚀和扩散。
The fluorouracil PLA-microspheres were prepared by solvent evaporation method. The formulation was optimized by orthogonal design using drug loading and the encapsulation efficiency as evaluation parameters. The product was spherical and had pores on surface. The average diameter was 801.tm, drug loading was 10% and encapsulation efficiency was 84%. The double phase dynamic model was the best choice for fitting the in vitro drug release profiles among several mathematical models, and the release mechanism was erosion and diffusion.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第4期245-247,共3页
Chinese Journal of Pharmaceuticals
关键词
氟尿嘧啶
聚乳酸
微球
体外释放
fluorouracil
PLA
microsphere
in vitro release
