摘要
实验观察生脉散对大鼠脑缺血－再灌注损伤的影响。结果表明，生脉散能使由脑缺血－再灌注诱发的脑含水量增加明显减轻，Ｎａ￣＋潴留显著改善，Ｋ￣＋向细胞外移出明显减少，ＬＤＨ和ＣＰＫ释放大大减少，脑组织内ＬＡ积聚水平明显减少，ＭＤＡ含量显著减少（均Ｐ＜０．０１）。实验证明，生脉散对脑缺血－再灌注诱发的脑损伤有明显的保护作用。
The protective effect of shenmaisan on cerebral ischemia-reperfusion injury were observed in ex-perimental rats.The result showed that after the treatment with shenmaisan the cerebral water and Na+content were lowered,lactate dehydrogenase(LDH)and creatine phosphokinase(CPK)released from brainduring cerebral reperfusion suppressed(P<0. 01,P<0.01),lactate and malondialdehyde(MDA) level de-creased(P<0. 01,P<0.01).These results indicate that Shenmaisan is effective in protecting the rat fromcerebral ischemia-reperfusion injury.Its mechenism was related to the inhibition of brain edema,intracellu-lar eiizymes release,lactate accumulation and lipid-preoxidation.
出处
《蚌埠医学院学报》
CAS
1996年第3期148-150,共3页
Journal of Bengbu Medical College
关键词
脑缺血
再灌注损伤
中药
生脉散
shenmaisan
transient cerebral ischemia
brain injuries
lactate dehydrogenase
creatine kinase
