摘要
目的探讨急性冠脉综合征(ACS)患者血浆脑钠肽(BNP)和C-反应蛋白(CRP)的变化及其临床意义。方法采用荧光免疫抗原抗体结合方法,37例稳定型心绞痛(SAP)患者入院后第2天清晨及123例ACS患者症状发作后平均(35.71±19.49)h的血浆BNP水平;采用ELISA法测定患者入院第2日清晨血浆CRP水平。测定以63例冠脉造影正常、心功能正常者,作为对照。结果ACS患者血浆BNP和CRP水平明显升高。血浆BNP水平ACS组分别高于SAP组及对照组(P均<0.0001)。CRP水平ACS组分别高于SAP组及对照组(P均<0.001)。ACS组血浆BNP水平和CRP水平呈正相关(r=0.41813,P<0.0001)。结论ACS患者血浆BNP和CRP水平明显升高,提示二者在ACS的发病机制中起重要作用。
Objective To explore the variation and significance of brain natriuretic peptide（BNP） and C-reactive protein（CRP） in patients with acute coronary syndrome （ACS）. Methods The study population consisted of 123 consecutive patients with ACS undergoing PCI, 37 patients with stable angina pectoris （SAP） and 63 patients with normal coronary artery angiography and cardiac function as control group between November 2004 and April 2005. Plasma BNP was measured by fluoroimmunoassay at 35.71 ± 19.49 hours in patients with ACS after the onset of ischemic symptoms,and CRP was measured by ELISA the next morning after admission. Results The plasma BNP level and CRP level increased significantly in patients with ACS. The plasma BNP level in ACS group was higher than that in SAP group and control group （P 〈0.0001 for both）. The plasma CRP level in ACS group was higher than that in SAP group and control group（P 〈0. 001 for both）. Conclusion Plasma BNP and CRP levels increase significantly in patients with ACS, which suggests that BNP and CRP play an important role in the pathophysiology of ACS.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2006年第3期241-243,共3页
Journal of Shanghai Jiao tong University:Medical Science
基金
上海市卫生局基金(044048)资助项目
