摘要
目的研究鲍曼不动杆菌所致的呼吸机相关性肺炎(VAP)的临床特点及不动杆菌的耐药性,为经验性抗生素治疗提供依据。方法回顾性分析了我院呼吸内科及急诊ICU自1997年1月至2004年12月期间鲍曼不动杆菌所致VAP的48例住院病人的临床资料及药敏情况。结果鲍曼不动杆菌所致VAP均有较严重的基础疾病,发病前曾使用一种或多种抗生素,27·1%有混合感染。8年间,每年鲍曼不动杆菌占VAP致病菌的百分率逐年上升。药敏结果显示不动杆菌有多重耐药性,对亚胺培南、头孢吡肟、含酶抑制剂的β内酰胺类抗生素的耐药性较低。结论不动杆菌所致VAP的经验性抗生素治疗应该根据本地区本医院最新的院内感染病原体分布及耐药性,合理选择抗生素。
Objective To investigate the clinical characteristics of ventilator-associated pneumonia（YAP） caused by Acinetobacter and its drug resistance so as to provide evidence for empiric antibiotic therapy.Methods The clinical resords and results of sputum cultivation and bacterial susceptibility of 48 eases of VAP caused by acinetobacter baumannii（A. B. ） between 1997 and 2004 in RICU and EICU of our hospital were reviewed. Results All of the patients suffered from severe basic diseases. At least one kind of antibiotic was used in all eases before the occurrence of VAP.27.1% of the eases had mixed infection.Percentage of VAP caused by A. B. had been increasing in the 8 years. The results of bacterial susoeptibility showed that acinetobacter had multiple drug resistance,but was lowly resistant to Imipencm, Cefepime and β-lactams with the component of enzyme depression. Conclusion Empiric antibiotic therapy of VAP caused by Acinetobacter should be based on the local latest surveillance of etiology and drug resistance.
出处
《广西医学》
CAS
2006年第1期40-41,共2页
Guangxi Medical Journal
