摘要
目的探讨乙型肝炎病毒前S1蛋白(PreS1)检测方法及在乙型肝炎病毒诊断中的临床意义。方法采用ELISA法对158例各型乙型肝炎病毒患者血清标志物PreS1进行检测,同时对每个标本进行HBV-DNA定量及乙肝“两对半”的双盲测定。比较各组PreS1、HBV-DNA、HBeAg三者之间的关系。结果PreS1在HBeAg阳性组合中的检出率为87.9%,明显高于HBeAg阴性组46.7%(P<0.01)。以乙肝病毒HBV-DNA≥103拷贝/毫升为判断乙肝病毒存在复制的标准,PreS1在HBV-DNA阳性组合的检出率为93.0%,明显高于HBV-DNA阴性组25.8%(P<0.01)。结论血清乙型肝炎病毒PreS1测定可以作为乙型肝炎病毒早期感染、复制及预后判断的重要指标。
Objective To discuss the way to detect hepatitis B virus Pre - S1 protein and its clinical signification for identifying viral replication in patients with HBV. Methods Pre - S1 protein in sera samples from 158 patients with HBV were detected by ELISA, at the same time each sample was estimated by HBV- DNA and HBV- Agcompare Pre - S1, HBV-DNA and HBeAg. Results Pre -S1 in HbeAg posifive group detectable rate is 87.9%, obviously, more higher than theHbeAg negative group 46. 796 （ P 〈 0.01 ） .＇This is a standard that to judged hepatitis B virus copying by HBV- DNA（≥103 copies/ml）. Pre - S1 in HBV- DNA positive group detectable rate is 93.0%, obviously, mote higher than the HBV - DNA negative group 25.8 % （ P 〈 0.01）. Conclusion Pre - S1 is a valuably serological marker for hepatitis B virus＇ inchoate infection, replication and prcgnostic judgement.
出处
《宁夏医学杂志》
CAS
2006年第3期204-205,共2页
Ningxia Medical Journal
