摘要
对本院１００例活检唇腺标本进行观察，结果发现原发性干燥综合征（１°ＳＳ）组和继发性干燥综合征（２°ＳＳ）组比较除纤维化在后者较多见外，腺体萎缩、导管扩张及淋巴细胞浸润在两者间无明显差异（Ｐ＞０．０５）。干燥综合征（ＳＳ）组与非结缔组织病（ＮｏｎＣＴＤ）组比较，上述各种病变间均有明显差异（Ｐ＜０．０１）。１°ＳＳ组中７８．５７％达到Ｃｈｉｓｈｏｌｍ分度的Ⅳ度，２°ＳＳ组中６５．２２％达到Ⅳ度，而非ＣＴＤ组仅２２．２２％有类似病变。按此标准，唇腺病理对ＳＳ诊断的敏感性和特异性分别为７８．８％和７７．１％。
To explore the sensitivity and specificity of the pathology of labial salibary gland in the diagnosis of Sjogren's syndrome(SS)and its specific pathological changes in SS,100 labialsalivary gland specimens were observed and assayed in our hospital.The results indicatedthat there was no significant difference in acinar atrophy,duct dilatation and lymphocytes in-filtration between primary SS(1°SS)and secondary SS( 2°SS)patients.But those changeshad significant difference between l°SS and nonCTD patients(P<0.0l).It was also foundin our study that Chisholm grade Ⅳ was achieved in 78.57%1°SS specimens,65.22%2°SSspecimeus and 22.22%in non-CTD specimens,respectively. According to Chisholm stan-dard,the sensitivity and specificity of pathology in the diagnosis of these SS patients was78.8%and 77.1%. Our patients were still classified by using Chisholm standard.If focallymphocytes infiltration was used as the single criterion to SS diagnosis,its specificity wasnot high.In the diagnosis of SS authors should consider the pathologic changes of salivarygland as well as the clinical information in order to avoid misdiagnosis.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1996年第1期19-22,共4页
Acta Academiae Medicinae Sinicae
关键词
干燥综合征
辰腺
病理
灶性
淋巴细胞浸润
诊断
Sjogren's syndrome
labial salivary gland pathology
focal lymphocytic infiItration
