摘要
目的:建立抗感冒注射液特定(指纹)图谱。方法:采用高效液相色谱梯度洗脱法,选用 Zorbax SB-C_(18)(4.6mm×250mm,5μm)色谱柱;流动相:(A)甲醇-0.05%磷酸(20:80),(B)乙腈-0.05%磷酸(40:60),梯度洗脱,采用线性梯度洗脱程序;流速:1mL·min^(-1);运行时间:70min;检测波长:328nm。结果:确定了抗感冒注射液的标准特定(指纹)图谱、各个中间体以及药材的标准特定(指纹)图谱。结论:本法可用于抗感冒注射液的中间体及成品的质量控制。
Objective： To develop specifically chromatography （fingerprint） technology for Kangganmao injection by HPLC. Method： Zorbax SB -C18（4. 6 mm ×250 mm,5μm） was used as the stationary phase,acetonitrile with 0. 05% phosphoric acid and methanol with 0. 05% phosphoric acid were used as mobile phase, and the photodiode array detector was used at 328 nm. Results：The standard specifically chromatography （fingerprint） technology was established for Kangganmao injection, its intermedia and Chinese medicinal materials. Conclusion： The method is applied to quality control of Kangganmao injection, intermedia and Chinese medicinal materials.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2006年第2期188-190,共3页
Chinese Journal of Pharmaceutical Analysis
