摘要
目的考察室温下注射用头孢噻肟钠与注射用氯诺昔康在0．9％氯化钠注射液中的配伍稳定性。方法在（25±1）℃下，采用高效液相色谱梯度洗脱法同时测定头孢噻肟钠与氯诺昔康在0．9％氯化钠注射液中配伍后6h内各时间点的含量变化，并观察和检测配伍液的外观及pH变化。结果配伍液6h内头孢噻肟钠与氯诺昔康的含量逐渐下降，pH随时间变化亦逐渐降低，溶液颜色随时间变化逐渐加深。结论室温条件下，注射用头孢噻肟钠与注射用氯诺昔康在0．9％氯化钠注射液中不稳定，临床应用应单独给药。
Objective To study the stability and compatibility of cefotaxime sodium injection with lornoxieam in 0. 9% sodium chloride injection （NS） at room temperature. Methods At （ 25 ＋ 1 ） ℃, the contents changes of cefotaxime sodium and lornoxicam in NS were determined simultaneously by gradient-elution high performance liquid chromatography at several time points after mixing within 6 hours. The appearance of mixing solution was observed and the pH value was determined. Results The relative percentage of cefotaxime and lornoxicam decreased for the mixed solution within 6 hours. The pH value decreased and the colour gradually deepened gradually. Conclusion The mixture of cefotaxime sodium injection with lornoxicam in NS at ambient temperature is unstable, accordingly clinical application should not be compatible.
出处
《中国医药》
2012年第10期1319-1320,共2页
China Medicine
关键词
头孢噻肟钠
氯诺昔康
高效液相色谱法
配伍
稳定性
Cefotaxime
Lornoxicam
High performance liquid chromatography
Compatibility
Stability
