摘要
目的探讨甲钴胺对慢性酒精中毒性周围神经病的治疗作用。方法健康成年日本大白兔40只,随机分为3组:安慰剂组、甲钴胺组和对照组。安慰剂组和甲钴胺组均以56°白酒按6ml·kg-1·d-1的剂量灌胃24周,对照组给予等体积生理盐水灌胃24周。24周后停止给酒,甲钴胺组给予甲钴胺注射液100μg·d-1,1次·d-1,肌注,连续4周;安慰剂组给予等体积生理盐水,1次·d-1,肌注,连续4周。4周后各组均行肌电图和坐骨神经病理检查。结果甲钴胺组家兔一般情况好于安慰剂组,肌电图和坐骨神经病理检查均显示周围神经病损害程度较安慰剂组轻。结论甲钴胺对慢性酒精中毒性周围神经病具有治疗作用。
Objective To investigate the mecohalamin treatment for peripheral neuropathy. Methods 40 healthy adult Japan rabbits were divided into three groups randomly. Two groups were administrated distilled spirit （56%,v/v）（ 6ml·kg^-1·d^-1）, and isovolume normal saline as contrals by pouring into stomach with a plastic tube. One of the group was given intramuscular injection mecohalamin 100 μg·d^-1 for 4 weeks after 24 weeks distilled spirit pouring. Electroneurophysiology and pathology of the sciatic nerve were determined after 24 weeks. Results Electroneurophysiology and pathology of the sciatic nerve were shown that mecobalamin can treat the chronic alcoholism peripheral neuropathy in rabbit. Condusions Mecobalamin could treat the chronic alcoholism peripheral neuropathy.
出处
《卒中与神经疾病》
2006年第1期40-43,共4页
Stroke and Nervous Diseases
关键词
酒精中毒
周围神经病模型
家兔
Alcoholism Peripheral neuropathy Mecobalamin rabbit
