摘要
采用生物活性玻璃(BG)、磷酸三钙(TCP)、羟基磷灰石(HA)等生物活性陶瓷与3-羟基丁酸酯-3-羟基戊酸酯的共聚物(PHBV)复合,制备了性能良好的骨组织工程支架材料,分析了PHBV／BG,PHBV／TCP,PHBV／HA三种复合多孔支架在模拟生理溶液中的一系列化学反应,以及多孔材料在模拟生理溶液中浸泡后的成分、结构和微观形貌的变化。研究结果表明,三种复合支架材料在模拟生理溶液中发生了降解反应而失重；PHBV／BG和PHBV／TCP在模拟生理溶液中还发生了生物矿化反应,在表面形成矿化沉积层,为具有骨生物活性的结晶态类骨碳酸羟基磷灰石；而PHBV／HA在模拟生理溶液中没有明显的生物活性反应。
Three kinds of porous composites based on poly（3-hydroxybutyrate-co-3-hydroxyvalerate） （PHBV） and bioactive glass （BG）, tricalcium phosphate （TCP）, hydroxyapatite （HA） respectively were prepared for born tissue engineering scaffolds. The chemical reactions and in vitro degradation of PHBV/ BG, PHBV/TCP and PHBV/HA porous materials under physiological condition were assessed and com- pared. The changes in surface micromorphology, composition and structure of the composite scaffolds were investigated before and after immersed in simulated body fluid （SBF） solution. It was found that biodegradation occurred for three kinds of scaffolds which led to the weight loss of the scaffolds after immersed in SBF solution. The biomineralized reaction and ion exchange reaction occurred in PHBV/BG and PHBV/ TCP scaffolds in SBF solution, and the mineralized layer formed on the surface of those scaffolds which was analyzed as hydroxyl carbonate apatite （HCA）. There was little biomineralized reaction appeared on PHBV/HA scaffolds during immersed in SBF sulotion.
出处
《北京科技大学学报》
EI
CAS
CSCD
北大核心
2006年第1期63-67,共5页
Journal of University of Science and Technology Beijing
基金
国家自然科学基金(No.59932050)广东省自然科学基金(No.990621)广东省重点科技攻关项目(No.A302020202)
