摘要
目的研究新型纳米仿生骨植入材料的体内降解性。方法制备犬胫骨骨缺损模型,实验组植入材料,空白对照组不作处理。术后2,4,8,12周取材,观察该材料的体内降解性及骨再生的效果。结果材料植入体内2周已开始降解,12周时材料基本完全降解,光镜下及电镜下均未见材料颗粒的残留,骨缺损区新骨充填,骨再生量明显优于对照组。结论新型纳米仿生骨植入材料体内降解速度快,材料降解后为新生骨组织所替代。
Objective To study the biodegradation of novel bionic scaffold with nanostructure in vivo. Methods Bone defects pierced through marrow were created bilaterally in the tibia of four dogs rspectively. Novel bionic scaffold were embedded into the defects in the experimental group, while defects without treatment were serves as control. Dogs were sacrificed 2, 4, 8, 12 weeks after operation respectively. Biodegradation - ability of novel bionic scaffold and effect of osteogenesis were examined. Results The novel bionic scaffold began to degrade 2 weeks postoperatively. There was almost completely absorption 12 weeks postoperatively, and no remnant of comosite was detected under light microscope and SEM. The bone regeneration in experimental group was signitficantly better than that in control group. Conclusion The novel bionic scaffold degraes quickly in vivo. Regeneration of new bone isaccompanied by degradation of the novel bionic scaffold.
出处
《广东医学》
CAS
CSCD
北大核心
2007年第8期1218-1220,共3页
Guangdong Medical Journal
基金
广东省科技计划项目(编号:2005B30901010)
广东省医学科学技术研究基金资助项目(编号:A2003049)
