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乙型肝炎病毒基因型分型方法研究进展 被引量:13

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摘要 乙型肝炎是由乙型肝炎病毒(HepatitisBVirus,HBV)引起的危害严重的传染病,HBV基因型与其危害程度有一定的相关性。目前有多种HBV基因型分型方法,包括核酸测序、聚合酶联反应限制性片段长度多态性(PCRRFLP)、单克隆抗体ELISA法、型特异性引物PCR法、PCR微板核酸杂交ELISA法、线性探针分析(Lineprobeassay,LiPA)基因分型法、实时定量PCR解链曲线分析(RealtimePCRandmeltingcurveanalysis)等。这些基因分型方法在HBV的临床诊断和流行病学调查应用中各有优缺点。
出处 《国际病毒学杂志》 2006年第1期26-29,共4页 International Journal of Virology
基金 国家自然科学基金(30560136)
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