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柴胡注射液对鼻粘膜纤毛毒性评价的研究 被引量:6

Toxicity Estimation of Chaihu Injection on Membrana Pituitosa Cilium
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摘要 目的:研究柴胡注射液对鼻粘膜纤毛运动的影响,并比较其在24h内使用不同给药间隔和给药次数对鼻粘膜纤毛运动的影响。方法:用显微镜观察离体蟾蜍上腭纤毛在柴胡注射液作用下持续摆动时间等,并以此为指标考查纤毛毒性受柴胡注射液的给药间隔和给药次数的影响。结果:柴胡注射液对鼻粘膜纤毛运动的影响不大;但给药间隔越短,给药次数越多,影响则增加。结论:柴胡注射液采用适宜的给药间隔和给药次数滴鼻是安全、可行的。 Objective: To investigate the influence of Chaihu injection on the movement of membrana pituitosa cilium, and compare its effect in different dosing interval and frequency among 24 hours. Method: the microscope was used to observe the persistence vibration time of ex vivo toad palate cilium at the action of Chaihu injection, and took it as targets to investigate the influence in using different interval and frequency of application of Chaihu Injection on Cilium toxicity. Result: Chaihu Injection has not obviously influences on cilium movement; while the shorter the interval of application of Chaihu Injection or the more the frequency of application of Chaihu Injection, the. more obvious effect. Conclusion; Chaihu injection was safe and feasible when used suitable interval and frequency to dropping nose.
出处 《中医药导报》 2006年第2期66-67,共2页 Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词 柴胡注射液 鼻腔给药 纤毛毒性 Chaihu Injection Dosing into nasal cavity Cilium toxicity
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