摘要
目的检测晚期恶性肿瘤患者血清瘦素(Leptin)和肿瘤坏死因子(TNF-α)浓度及与肿瘤恶液质形成的关系。方法采用放射免疫法测定87例恶性肿瘤患者和75例正常人的血清瘦素和TNF-α,并分析体重指数(BMI)、三头肌皮皱厚度(TSF)、上臂中部臂围(MAC)和血清白蛋白(ALB)等营养参数与血清瘦素和TNF-α的关系。结果恶性肿瘤患者的血清瘦素水平下降,TNF-α浓度升高,与对照组比较差异有显著性(P<0.01);血清瘦素与TNF-α两组间无相关性(P>0.05),但血清瘦素水平与BMI、TSF、MAC呈正相关。结论恶性肿瘤患者的血清瘦素水平下降,TNF-α水平升高,其血清低瘦素水平不能刺激食欲增加,体重恢复,提示瘦素可能参与恶性肿瘤恶液质的发生。
Objective To detect concentration of serum leptin and tumor necrosis factor-α （TNF-α）, and to study the association of leptin and TNF-α with cachexia in the paients with malignant tumor. Methods Serum Leptin and TNF-α concentrations were measured by radio immunoassay in 87 patients with developing malignant tumor and in 75 controls, and analyzed the relationship between the leptin and TNF-α and nutritional parameters, body mass index （BMI）, TSF （triceps skin- fold thickness）, MAC （mid- upper arm circumference）, serum albumin （ALB）. Results The level of serum leptin in the malignant tumor patients were lower significantly than that of the normal people （ P 〈 0.01 ）, whereas serum TNF-α concentration were higher than that in control. There is no correlation between TNF-α and leptin, and the leptin levels were significantly correlated with BMI, TSF, MAC in the tumor patients. Conclusion The lower leptin level in the malignant tumor patients can＇t stimulate their appetite and weight - increasing, suggesting that leptin may contribute to malignant tumor cachexia.
出处
《实用肿瘤学杂志》
CAS
2006年第1期7-8,33,共3页
Practical Oncology Journal
关键词
瘦素
肿瘤坏死因子
恶液质
恶性肿瘤
Leptin
Tumor necrosis factror-α
Cachexia
Malignant tumor
