摘要
目的:观察补肾中药对去势后大鼠雌激素受体基因表达的影响。方法:雌性SD大鼠去势后给予高脂饲料喂养,制作绝经后动脉粥样硬化模型,同时每日给予补肾中药灌胃。16周后检测血脂水平,主动脉、垂体和下丘脑雌激素受体α、β基因的表达以及雌激素受体-配体结合力。结果:补肾中药可提高主动脉、垂体和下丘脑雌激素受体α、β基因的表达,并提高主动脉和下丘脑组织雌激素受体-配体结合力。结论:补肾中药可能通过调节雌激素受体而对绝经后动脉粥样硬化起改善作用。
Objective： To observe the effects of recipe for invigorating kidney on expression of estrogen receptors in ovariectomized rats. Methods： The rats, which were given high-cholesterol diet after ovariectomy, were chosen as experimental subjects. After fed kidney-invigorating recipe for 16 weeks, the rats were killed and the levels of serum lipid and estradiol of these rats were examined. The expressions of estrogen receptor α and β mRNAs in aorta, pituitary gland and hypothalamus, and the affinity of estrogen receptor-ligand were also detected. Results： The kidney-invigorating recipe could increase the expression levels of estrogen receptor a and [3 mRNAs in different parts such as aorta, pituitary gland and hypothalamus, and enhance the affinity of estrogen receptor-ligands. Conclusion： The recipe for invigorating kidney may meliorate atherosclerosis in ovariectomized rats by regulating the estrogen receptors.
出处
《中西医结合学报》
CAS
2006年第1期26-29,共4页
Journal of Chinese Integrative Medicine
基金
国家自然科学基金资助项目(No.30271664)
关键词
绝经
动脉硬化
受体
雌激素
menopause
arteriosclerosis
receptors, estrogen
