摘要
目的:介绍制造业高新技术快速成形技术的基本原理与特点,将其应用于颅颌面外科的临床,以及组织工程的支架的制备,并分析其在颅颌面外科应用的可能性与前景。方法:从1998-12/2005-02选取中国协和医科大学整形外科医院颅颌面外科中心入院的31例患者,运用快速成形技术制备模型及山羊组织工程试验的支架,首先使用CT扫描,CT图像在工作站进行三维重建,最终的数据转换为快速成形机所能接受的文件格式,成形机通过“分层制造、逐层叠加”的原理制造出三维模型;相同方法快速成形技术用于制造骨组织工程支架材料。结果:①利用三维模型,完成了31例患者的三维测量、临床诊断、模拟手术和骨缺损修复体的术前预制,高了诊疗质量。②制造的骨支架材料,提其内部结构是由400μm大孔与5μm小孔组成的,孔隙率80%,能够设计、制作出类似天然骨组织内部的三维孔腔结构。结论:利用快速成形技术制造的仿生模型及修复体是颅颌面外科不可替代的工具;构建的支架材料是组织工程研究的一个新方向;在颅颌面外科领域的应用有较大的临床意义。
AIM： To introduce the basic theories and procedures of rapid prototyping, an advanced manufacture technique, and its application for craniomaxillofacial surgery and tissue engineering. METHODS： Thirty-one patients were selected from the Department of Craniomaxillofacial Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College between December 1998 and February 2005. Electron beam computed tomography （EBCT） scanner was employed to scan patients heads and faces in series and thin layers. Data of EBCT were input in workstation from digital inlet, then to three-dimensional reconstruction with method of surface shadow. After final data to be transformed to the files, which rapid prototyping machine can identify, the data were input laser rapid prototyping machine. Three-dimensional bionic cranium models were fabricated by machine in layerby-layer manufacturing principle. The scaffold of tissue engineering also can be fabricated by same procedure with controlled porous architecture, configuration, and shape. RESULTS： ①Accurate three-dimensional gauging, clinical diagnosis, simulate surgeries and prefabrication of individual prosthesis for bone defect were performed in thirty one patients with craniomaxillofacial anonmalies by using the three-dimensional bionic models, which made surgeries simple and accurate.② The macro pore dimension was about 400 μm in size. The high-magnified image shows that there was a＇ micro porous structure around the macro pores. The average micro pore dimension is about 5μm. The average porosity of the scaffold was 80%. CONCLUSION： Bionic models have become a very useful and important tools for modern craniomaxillofacial surgery. Scaffold of tissue engineering by rapid prototyping is bioactive material, and it is new research direction to tissue engineering.
出处
《中国临床康复》
CSCD
北大核心
2006年第1期103-105,i0006,共4页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助(30471798)~~
