摘要
目的:探讨散发性结直肠癌组织中脆性组氨酸三联体(fragile histidinetriad,FHIT)蛋白表达情况及其与临床病理指标之间的关系。方法:采用免疫组化SP法检测84例手术切除的散发性结直肠癌组织中FHIT蛋白的表达。结果:FHIT蛋白在84例散发性结直肠癌中表达阳性率为48·81%。FHIT蛋白低或不表达与患者的年龄、性别、肿瘤部位、组织学类型无关,P>0·05;而与肿瘤浸润深度和分化程度、Duck’s分期和淋巴结转移有关,P<0·05。在浸润深度越深、分化程度越低、Duck’s分期越晚和有淋巴结转移的癌组织中,FHIT蛋白低表达就越明显。结论:FHIT蛋白表达缺失可能参与散发性结直肠癌的演化和进展。
OBJECTIVE： To investigate the expression of fragile histidine triad （FHIT） protein and its correlation with clinicopathological features of human sporadic colorectal carcinoma （SCC）. METHODS： Immunohistochemistry SP method was used to determine the expression of FHIT protein in surgically resected specimens of 84 human SCC. RESULTS： The positive rate of FHIT protein expression was 48. 81% in human SCC. No correlation was found of loss or reduced expression of FHIT protein with tumors clinicopathological features such as age,gender,tumous site and histological type,P〉0. 05, but the correlation was found of loss or reduced expression of HIT protein with tumors invade depth, degree of the differentiation, Duck＇s stage and metastasis, P〈0. 05. Tumous with deeper invade depth, lower differentiation degree, later Duck＇ s stage and lymph node metastasis were significantly more likely to be reduction for FHIT protein the expression. CONCLUSION： Absent or reduction of FHIT protein expression possiably takes part in development and progression of human SCC.
出处
《肿瘤防治杂志》
2005年第24期1884-1887,共4页
China Journal of Cancer Prevention and Treatment
