摘要
对２１例胸腔恶性肿瘤和８例胸腔良性肿瘤二组患者围术期作ＮＫ细胞活力、血浆ＳＩＬ－２Ｒ表达水平的动态监测结果表明：胸腔恶性肿瘤患者ＮＫ细胞活力明显低于良性肿瘤组（Ｐ＜０．０５），血浆ＳＩＬ－２Ｒ表达水平明显高于良性肿瘤组（Ｐ＜０．００１）；二组患者在术始２～３小时ＮＫ活性均明显升高，术后３～５天则显著回落，而ＳＩＬ－２Ｒ水平则表现为一反向变化。结果提示胸腔恶性肿瘤患者抗肿瘤免疫功能严重受损；术中ＮＫ细胞活性一过性升高可能对手术操作引起的肿瘤细胞播散有遏制作用，但术后免疫功能的抑制对防止肿瘤的复发和转移是不利的。
The peripheral blood NK activity,SIL 2R expression of 21 patients with malignant and 8 patients with benign pleural cavity tumors were studied during perioperative time.The results indicated that the NK activity of the malignant tumor group was signiicantly lower than that of the benign tumor group( P <0 05)and that the SIL 2R expression of malignant group was significantly higher than that of benign tumor group( P <0 001).It showed that the NK activities of two groups were significantly elevated 2～3 hours after operation and significantly reversed 3～5 days after surgery,and that the changes of SIL 2R expression showed a opposite change to that of NK activity. The results suggested that the immunity of patients with malignant pleural cavity tumor was significantly dim inished and that the increased NK activity within the operation time might play an important role in defending the disemination of the tumor cells,but the depressed immunity postoperatively might be harmful.
出处
《中国胸心血管外科临床杂志》
CAS
1996年第3期169-171,共3页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
胸腔肿瘤
杀伤细胞
天然
白细胞介素2
受体
Tumor/immunity
Natural Killer cell(NK)
Soluble Interleukin 2 Receptor(SIL 2R)
