摘要
目的观察冠心病病人支架置入术前后炎性指标的变化。方法选择2003年10月至2004年12月期间于我院行支架置入术的心绞痛及心肌梗死病人35例,以同期行冠脉造影病人18例为对照组,分别于手术前后不同时间点采集静脉血样,用ELLISA法检测白细胞介素-8(IL-8)和单核细胞趋化蛋白-1(MCP)。结果术后炎性因子较术前升高明显(P<0.01),高危病变组和中危病变组的IL-8和CRP高于低危病变组(P>0.05);CGC组和CGB组高于CGA组(P<0.05)。结论PCI导致冠脉局部炎性反应增强,危险病变及复杂操作病变炎性反应程度亦高。
Objective To observe changes of chemoking after percrtaneous coronary intervention （PCI） Methods Vessel blood of 35 patients with PCI and 8 patients with coronary anglography were selected at deferent time points. IL-8 and MCP-1 were measured by ELLISA. Results Plasm level of IL-8, MCP-1 was higher in group of secondary and high risk lesion than low risk lesion group （12h： IL-8, P〈0.01; 48h： MCP-1, CRP , P〈0.01） . The plasm level of IL- 8, MCP- 1 was higher in 12h or 48h group CGC and COB than in group COA （P〈0.05）, and was higher in group CGC than in group COB . Conclusions PCI therapy interferes with the detrimental effects of inflammation on accelerated atherosclerotic disease progression following coronary stenting. And the degree of increasing plasm chemokine may be a indirect digit of injury by operation.
出处
《锦州医学院学报》
2005年第6期48-50,共3页
Journal of Jinzhou Medical College
