摘要
目的研究心力衰竭患者血中N端脑钠肽前体(NT-proBNP)水平与心力衰竭及心功能的关系。方法采用电化学法(ECLIA)测定87例心力衰竭患者和11例正常人血清NT-proBNP水平,用心脏彩色多普勒诊断仪测定其左室舒张末径(LVDd)、左室射血分数(LVEF)。结果心力衰竭患者血中BNP水平明显高于正常对照组,并随着心功能纽约分级(NYHA)程度的加重而显著增加,与左室舒张末径(LVDd)呈正相关(r=0.40,P<0.01),与左室射血分数(LVEF)呈负相关(r=-0.62.,P<0.01)。结论NT-proBNP水平可以作为诊断心力衰竭的一个很好的指标,且心力衰竭患者血中的NT-proBNP水平随着心功能的恶化而增加,能较好地反映左室的功能。
Objective To study the correlation in level of serum N terminal pro-brain natriuretic peptide,heart failure and function. Methods The level of serum N terminal pro-brain natriuretic peptide from 87 patients with heart failure and 11 healthy adults were measured by ECLIA,LVDd and LVEF were examined by colored Doppler echocardiography. Results The level of N terminal pro-brain natriuretic peptide in patients with heart failure was obviously higher than that of the normal and increased with the increment of NYHA classification. The results showed that NT-proBNP was positively related to LVDd（ r = 0.40, P 〈 0.01） but negatively to EF （r = -0.62, P 〈 0.01）. Conclusion The level of NT-proBNP can be an ideal indication in diagnosis of heart failure since it will increase with the degree of severity of heart failure demonstrating the function of the left ventricular.
出处
《皖南医学院学报》
CAS
2006年第1期29-31,共3页
Journal of Wannan Medical College
基金
广州市医药卫生科技基金项目(2003012)
关键词
N端脑钠肽前体
心力衰竭
心脏功能
诊断
N terminal pro-brain natriuretic peptide
heart failure
heart function
