摘要
目的探讨慢性肺心病(以下简称肺心病)急性期血清乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、肌酸磷酸激酶(CK)及其同工酶(CK-MB)、α-羟丁酸脱氢酶(HBDH)活性变化及临床意义。方法检测15例正常对照组、61例肺心病急性期患者治疗前后血清LDH、AST、ALT、CK、CK-MB及HBDH含量,并计算CK-MB/CK及HBDH/LDH,同时取动脉血做血气分析。结果肺心病患者治疗前血清LDH、AST、ALT、CK、CK-MB及HBDH含量明显高于治疗后血清酶含量(P<0.01或P<0.001),治疗后血清酶含量又明显高于正常对照组(P<0.05或P<0.01);血清酶值变化与PaO2呈显著性负相关,与PaCO2呈显著性正相关。结论缺氧和二氧化碳潴留引起的多脏器损伤是肺心病急性期血清酶变化的重要原因;伴发病是酶学变化的次要原因,但具有重要意义。因此正确分析酶学变化特点对鉴别诊断及疾病预后至关重要。
Objective To explore the changes of several sero- enzyme activity including lactate dehydrogenase （LDH）, aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, creeatine phosphatase kinase （CPK） and its isoenzyme （CK-MB） ,α-hdroxybutyrate dehydrogenase （FIBDH） in patients with chronic cor disease and its clinical significance. Methods The sera LDH, AST, ALT, CPK,CPK- MB and HBDH from 15 healthy controls and 61 patients with chronic cor disease were examined before and after treatment. CPK - MB/CPK and HBDH/LDH were calculated and simultaneously the blood gas analysis was performed. Results In experimental group all the sera enzymes contents before treatment were significantly higher than those after treatment （ P 〈 0.01 or P 〈 0. 001）, while in control group all the sera enzymes contents were significantly lower than those in experimental group. The changes of sera enzymes contents presented significandy negative correlation with PaO2 and significantly positive correlation with PaCO2. Conclusion Hypoxia and carbon dioxide retention induce multiple organ failure contributed mostly to the changes of sero - enzyme in patients with chronic cor dis- ease. The abnormality of enzymology was also seen in the important concomitant disease of chronic cor disease. Correct analysis of the characteristics of the enzymology changes is critical to the differential diagnosis and Drognosis of the disease.
出处
《中国医师进修杂志（内科版）》
2006年第2期25-27,共3页
Chinese Journal of Postgraduates of Medicine
关键词
血清酶
伴发病
Seri-enzyme
Concomitant disease
