摘要
目的探索5-羟色胺2A(5-HT_(2A))受体基因启动子区-1438G/A多态性与情感性障碍易感性的关系。方法采用限制性片断长度多态性(RFLP)分析技术,检测情感性障碍和正常对照组的5-HT_(2A)受体基因-1438G/A多态性的基因型和等位基因频率,并根据Hardy-Weinberg遗传平衡法则,比较相互之间的区别。结果1.抑郁症5-HT_(2A)受体基因-1438G/A多态性基因型A1/A1频率(58.51%)较正常对照组(42.86%)高,差异有显著性(2=3.929,P<0.05);2.伴有自杀企图或行为的情感性障碍患者5-HT_(2A)受体基因-1438G/A多态性基因型A1/A2的频率(25.45%)较正常对照组(38.46%)偏低,差异有显著性(2=4.74,P<0.05)。结论5-HT_(2A)受体基因-1438G/A多态性与抑郁症特别是具有自杀企图或行为的患者关联,提示该受体基因多态性可能是抑郁症的易感因子。
Objective To explore the association between 5-HT2A receptor gene promoter -1438G/A polymorphism and affective disorders. Methods Genotype and allele frequencies -1438G/A polymorphism of 5-HT2A receptor gene in affective disorder and normal controls were examined by PCR-RFLP technique and their difference was compared according to Hardy-Weinberg genetics balance rule. Results The genotype A1/A1 frequence of 5- HT2A receptor gene -1438G/A polymorphism in depression is higher than that in normal controls（ x^2 = 3. 929, P〈 0.05） and affective disorder patients with suicide attempt or behavior have a lower 5-HT2A receptor gene - 1438G/A A1/A2 genotypes frequency compare with normal control＇ s （ x^2 = 4.74, P 〈 0.05 ）. Conclusion 5- HT2A receptor gene -1438G/A polymorphism has an association with depressive patients, especially patients with suicide attempt or behavior, which suggest it may be responsible for a increase in susceptibility for depression.
出处
《中国行为医学科学》
CSCD
2006年第1期4-6,共3页
Chinese Journal of Behavioral Medical Science
基金
国家自然科学基金资助课题(30270496)
