摘要
目的探讨同型半胱氨酸(Hcy)与脑血管病(CVD)的关系。方法采用高效液相色谱分析法,检测34例脑出血(CH)及59例脑梗死(CI)患者的Hcy,并与29名同龄健康对照组比较。结果CVD组有40例伴Hcy升高,占43.0%,平均血浆Hcy水平(18.28±12.60)μmol L,明显高于对照组(10.17±3.68)μmol L(P<0.01),但CH组与CI组之间无显著差异(P>0.05)。结论高Hcy血症不但与CI有关,而且与CH也密切相关,是CVD的独立危险因素之一。
Objective To study the relationship between homocysteine （Hcy） and cerebrovascular disorder （CVD） .Methods The high - pefformance hquid chromatography was used to detect the plasma Hcy in 34 cerebral hemorrhage （CH）, 59 cerebral infarction （CI） patients and 29 age matched controls. Results There were 40 cases with increased plasma Hcy in CVD group, accounting for 43.0%, mean plasma Hcy level was 18.28 ± 12.60μmol/L , which was significendy lfigher in CVD group than in controls （ 10.17 ± 3.68μmol/L , P 〈 0.001 ）, but that were no significendy differencc betwecn CH CH proup and CI group （P〉 0.05） . Conclusion There is a close relationship between hyperhomocysteinemia and CI or CH, hyperhomocysteinemia is an independent risk factor for CVD.
关键词
同型半胱氨酸
脑血管病
脑出血
脑梗死
Homocysteine
Cerebrovascular disorder
Cerebral hemorrhage
Cerebral infarction
