摘要
目的:探讨慢性丙型肝炎(CHC)患者主要血清体液免疫指标的改变及其临床意义。方法:比较32例CHC患者和30例对照者的血清免疫球蛋白、循环免疫复合物(CIC)和补体水平。结果:CHC组IgG和IgM含量分别为17．2±3．68g／L和2．04±0．83g／L,显著高于正常对照组(P<0．01)。IgA含量略有升高,但和对照组相比无显著差异。C3、C4的含量分别为0．98±0．3g／L和0．19±0．075 g／L,低于正常对照组(P<0．01)。CHC组和对照组CIC含量分别为24．15±6．37mg／L和16．48±5．91mg／L,两组有显著差异(P< 0．01)。CHC组总蛋白和球蛋白的含量分别为77．2±8．16 g／L和35．0±5．19 g／L,高于正常对照组(P<0．05);白球比为1．23±0．26, 低于正常对照组(P<0．01)。结论:HCV慢性感染的病例,机体的体液免疫反应发生改变,动态监测HCV患者血清中的免疫球蛋白、补体及其CIC指标有助于疾病的诊断、治疗和预后判定。
Objective.. To explore change of humoral immunity indexes in chronic hepatitis C patients （CHC）and its clinical implication. Methods： The serum immunoglobulin（IgG, IgM and IgA）, complements （C3 and （24） and circulation immunity complex（CIC） were compared in 32 CHC and cantrols. Results： The results showed that the levels of IgG , IgM,and CIC in CHC group were significantly higher than thote of the control group（P〈0. 01 ）. However, levels of C3 and C4 were lower than those of the control group （P〈0. 01）. Furthermore, with the increases of total protein and globulin, the ratio of albumin to globulin decreased significantly in CHC group（P〈 0. 01 ）. Conclusion： These results suggested that humoral immunity responses should be impaired specially because of the liver disfunction after chronic hepatitis C virus infection and the dynamic surveillance on immunoglobulin, complements and CIC series could be beneficial to diagnosis and treatment of hepatitis C.
出处
《中国临床医学》
北大核心
2005年第6期1031-1033,共3页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金资助项目(30200232)
关键词
慢性丙型肝炎
免疫球蛋白
补体
循环免疫复合物
Chronic hepatitis C3 Immunoglobulim Complement
Circulation immunity complex
