摘要
目的研究白细胞介素-1(IL-1)基因多态性与原发性高血压的相关关系.方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测150例原发性高血压患者和160例健康对照者IL-1基因多态性.结果 IL-1α基因-889C/T多态性在两组人群中的分布差异显著(P＜0.05);等位基因频率的相对风险分析发现,T等位基因携带者患原发性高血压的风险是C等位基因的2.102倍(OR=2.102,95%CI:1.231～3.590),携带CT+TT基因型的原发性高血压患者收缩压水平显著高于CC基因型者[(168.9±19.8)mmHg比较(160.2±18.9)mmHg],(P＜0.05).结论 IL-1α基因-889C/T多态性与原发性高血压的发病具有相关性,其中T等位基因可能是原发性高血压发病的遗传易感基因,携带T等位基因的个体可能通过促进收缩压的升高进而增加了原发性高血压的发病风险.
Objective To study the relationship between the polymorphisms of interleukin-1 and essential hypertension in Chinese Han peoples. Methods The polymorphisms of IL-1 gene were analyzed by the polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） methods in 150 patients with essential hypertension and 160 healthy controls. Results The IL-1 α - 889C/T gene was significantly different（ P 〈 0.05）. The relative risk suffered from essential hypertension of C allele was 2.102 times of the T allele （OR = 2. 102,95 % CI： 1.231 ～ 3. 590）. The systolic blood pressure level of IL-1 α CT ＋ tit genotype carriers was significantly higher than of CC genotype carriers [ （ 168.9 ± 19.8） mmHg vs （160.2 ± 18.9）mmHg, P 〈 0.05]. Conclusion IL-1 α - 889C/T polymorphism was associated with essential hypertension, and T allele may be a risk factor for essential hypertension, in which the IL-1 α T allele carriers may have increased risk by enhancing the systolic blood pressure expression in the pathogenesis of essential hypertension.
出处
《基础医学与临床》
CSCD
北大核心
2005年第12期1130-1134,共5页
Basic and Clinical Medicine
基金
广西科学基金(桂科自0499004)
广西教育厅课题(桂教科200420)
右江民族医学院课题(右医院字200486)
