摘要
目的合成巴洛沙星(Balofloxacin),并进行工艺优化。方法以1-环丙基-6,7-二氟-8-甲氧基-4-氧代-1,4二氢喹啉-3-羧酸乙酯为起始原料,经保护、缩合、水解等反应制得抗菌药巴洛沙星。结果合成目标化合物,总收率为54.9%。结论本工艺反应条件平和,成本较低,收率较高。
AIM To synthesize balofloxacin and improve the synthetic procedure. MMETHOD Balofloxacin, an antibiotic, was synthesized through protection, reduction and hydrolysis from 1-cyclopropyl-6, 7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinollne carboxylic acid ethyl ester. RESULT Balofloxacin was synthesized successfully and in a total yield of 54.9%. CONCLUSION Tiffs improved procedure is applicable to industry.
出处
《江苏药学与临床研究》
2005年第6期11-12,共2页
Jiangsu Pharmacertical and Clinical Research
关键词
巴洛沙星
抗菌药
化学合成
Balofloxacin
Antibiotic
Chemical synthesis
