摘要
目的研究低分子肝素超氧化物歧化酶结合物(LWMHSOD)对低糖低氧损伤的神经细胞的保护作用。方法采用体外培养的大鼠大脑皮层神经元,造成低糖低氧损伤模型,观察LMWHSOD抗氧化损伤及对神经细胞的保护作用。结果LMWHSOD能够减少低糖低氧造成的细胞死亡,降低损伤后细胞外液LDH、MDA、NO的含量,改善细胞膜的流动性。结论LMWHSOD对神经细胞具有保护作用。
Aim To investigate the protective effects of LMWH-SOD（ Low molecular weight heparin- Superoxide dismutase Conjugate）on the injuries induced by oxygen and glucose deprivation in cultured neurons.Methods The cortical neurons of fetal rat were cultured in vitro. The antioxidant and protective effects of LMWH-SOD were observed by treating neurons with oxygen and glucose deprivation. Results LMWHSOD reduced the number of cell death and the efflux of LDH and the content of NO, MDA and increased the membrane fluidity after the injuries of cells. Conehlsion LMWH-SOD has protective effects on cerebral cortical neurons through its action of scavenging free radicals.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第12期1463-1466,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30270492)
关键词
LMWH—SOD
神经细胞
低糖低氧
LMWH-SOD
cerebral cortical neurons
oxygen and glucose deprivation
