摘要
目的变应性肉芽肿血管炎(CSS)是一种病因不清的少见的系统性血管炎。通过分析病例系列以描述疾病的临床特征、治疗和病情随访。方法回顾性地收集8例2000—2005年我院风湿科住院CSS患者,分析临床及实验室特征。结果所有CSS患者都有哮喘和嗜酸粒细胞增高。肺、皮肤和周围神经系统是最常累及的器官。多数患者接受了静脉滴注甲基泼尼龙冲击治疗,0.5g/d,连续3d,随后静脉注射环磷酰胺(CTX)750mg/m2,每月用1g,共6￣8次治疗,疗效好,长期随防病情稳定。结论CSS是系统性血管炎,有哮喘病史,联合免疫抑制治疗可取得较好的疗效。
Objective Churg-Strauss syndrome （CSS） is a rare muhisystem vasculitis of unknown aetiology. To describe the clinical features of the disease, the treatment and long-term follow-up. Methods Eight CSS patients were selected from rheumatology department of guangdong province peoples hospital between 2000--2005. Data were obtained retrospectively. The patients＇ clinical manifestation and laboratory result were studied. Results All patients had asthma and hypereosinophilia. The lung,skin and peripheral nervous system were the most commonly involved organs. The majority of patient received intravenous injection pulses of methylprednisolone 0.5 g/d×3 d, followed by per oral prednison 1 mg·kg^-1·d^-1 and intravenous injection pulses of cyclophosphamide 750 mg/m^2. The outcome and long-term follow-up were good. Conclusion Churgtrauss syndrome is a systemic vasculitis occurring in patients with a history of asthma, corticosteroids and immunosuppressive treatment may received good outcome.
出处
《中华风湿病学杂志》
CAS
CSCD
2005年第12期743-745,共3页
Chinese Journal of Rheumatology
