摘要
制备了硫酸酯化魔芋葡甘聚糖凝胶颗粒血液低密度脂蛋白吸附剂,扫描电镜观察产物呈交联网状多孔结构。体外静态吸附实验表明:在37℃振荡吸附2h后,对总胆固醇(TC)、低密度脂蛋白及超低密度脂蛋白胆固醇(LDL+VLDL-C)、高密度脂蛋白胆固醇(HDL-C)的吸附率分别为52.68%、54.76%、27.78%。通过吸附动力学曲线和吸附等温线分析,吸附剂对LDL+VLDL-C的作用包括类似分子筛的吸附和电荷间静电相互作用两种方式。
A novel adsorbent of low-density lipoprotein in blood sulfated konjac glucomannan gel particles were prepared in this work. SEM showed that the particles possessed cross-linked porous network structure. In vitro static adsorption indicated that after vibrated at 37℃ for 2h the adsorption rates for total cholesterol（TC） ,low-density and very low-density lipoprotein（ LDL ＋ VLDL-C）, high-density lipoprotein cholesterol （HDL-C） were 52.68 %, 54.76 % and 27.78 % respectively. Curve of adsorption kinetics and isotherm of the product showed that LDL was adsorbed by two way including the binding force similar to the molecular sieve and the electrostatic interaction between electric charges.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
2005年第6期771-774,共4页
Chinese Journal of Biomedical Engineering
基金
湖北省教育厅科技攻关项目(2000A04013)
关键词
魔芋葡甘聚糖硫酸酯
微观形貌
低密度脂蛋白
吸附行为
sulfated konjac glucomannan
microtopography
low-density lipoprotein
adsorption behavior
