摘要
以黄原胶为原料,进行酸降解,再以氯乙酸为羧甲基化试剂,在适当的条件下进行羧甲基化反应,获得降解黄原胶羧甲基化衍生物。考察分子质量及酸碱比对产物羧甲基含量的影响,确立较优化的羧甲基化反应条件。并通过红外对结构进行了表征。以降解黄原胶羧甲基化衍生物为净化剂,研究其选择清除血浆中低密度脂蛋白(LDL)及纤维蛋白原(Fib)的性能。结果表明,在pH=5.20,净化剂浓度为2,500mg/L时,可使血浆总胆固醇(TC)下降40%左右,低密度脂蛋白胆固醇下降45%,纤维蛋白原下降近100%,而总蛋白和高密度脂蛋白(HDL)无明显变化。
Degraded xanthate gum was prepared by aid with xanthate gum as main material,and then reacted with mono-chloroacetic acid under proper conditions.The effects of concentration of chloroacetic acid,the Mw of degraded gum on the degree of substitution of carboxymethyl xanthate gum were investigated.And the selective removal of low density lipoprotein(LDL) and fibrinogen(Fib) by degraded carboxyethyl xanthate gum was studied.The experimental results showed that degraded carboxyethyl xanthate gum is a novel LDL/...
出处
《中国血液流变学杂志》
CAS
2008年第4期476-480,共5页
Chinese Journal of Hemorheology
