摘要
目的:探讨胰腺组织中蛋白激酶Cα(PKCα)和整合素β1的表达及其临床意义。方法:采用免疫组织化学SP方法,检测56例胰腺癌(高、中分化36例,低分化20例;TNM分期Ⅰ～Ⅱ期24例,Ⅲ～Ⅳ期32例;有淋巴结转移30例,无淋巴结转移26例)及23例正常胰腺组织中PKCα和整合素β1的高表达情况。结果:胰腺癌组织中PKCα和整合素β1高表达率分别为62.50%和71.43%,均高于正常胰腺组织(21.74%,43.48%;P均<0.05);PKCα高表达与胰腺癌分化程度、TNM分期和淋巴结转移有关,整合素β1高表达与胰腺癌TNM分期和淋巴结转移有关。在胰腺癌组织中,PKCα表达与整合素β1呈正相关。结论:PKCα和整合素β1的表达和(或)功能异常可能共同参与胰腺癌的发生发展,联合检测2种蛋白对于预测胰腺癌转移潜能具有一定参考价值。
Aim ： To investigate the expression of protein kinase C-α（PKCα） and integrinβ1 in pancreatic carcinoma tissue. Methods ： The expression of PKCα and integrinβ1 in 56 cases of pancreatic carcinoma and 23 cases of normal pancreatic tissue were studied using immunohistochemical staining technique. Results：The increased expression rates of PKCαand intergrinβ1 in pancreatic neoplasm tissue were 62.50% , and 71.43% , which were significantly higher than those in normal pancreatic tissue, respectively（ 21.74% ,43.48% , P 〈 0.05 ） ; the increased PKCα expression was correlated with differentiation degree, TNM stage, and lymphatic metastasis; the increased integrinβ1 expression was correlated with TNM stage and lymphatic metastasis. In pancreatic carcinomas tissue,the expression of PKCα was positively correlated with that of integrinβ1. Conclusion：PKCα and integrinβ1 may play an important role in the carcinogenesis and tumor progression of pancreatic cancinoma, and they may be useful parameters for predicting tumor invasion and metastasis.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2005年第6期1096-1098,共3页
Journal of Zhengzhou University(Medical Sciences)
