摘要
西洋参茎叶皂甙对离体家兔胸主动脉条的作用吴捷，于晓江，刘传镐（西安医科大学临床药理研究所，西安７１００６１）西洋参茎叶皂甙（ｓａｐｏｎｉｎｓｏｆＰａｎａｘｑｕｉｎｑｕｅ－ｆｏｌｉｕｍｌｅａｆａｎｄｓｔｅｍ，ＳＰＱ）系从西洋参地上部分提取的总皂甙，具有...
The effects of saponins of Panaxquinquefolium leaf and stem(SPQ)on the KCl-aCl2 and norepinephrine(NE)-induced contrac-tions of isolated rabbit aortic strips were studied.SPQantagonised the contractions induced by KCl,CaCl2 and NE in a non-competitive manner.Theblockade effect of SPQ on the NE-induced contrac-tion was the same as on the potassium depolarized-in-duced one.To the intracellular Ca2+-dependent compo-nent of NE-induced contraction, SPQ exerted the obvi-ous blockad action only at higher concentration. Theresults suggest that the effect of SPQ blocking theCa2+ channel on vascular smooth muscle might be re-lated to the inhibition of Ca2+ influx through potentialdependent Ca2+ channel and receptor operatedCa2+ channel.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1995年第2期155-156,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
西洋参
茎叶
皂甙
胸主动脉条
家兔
saponins,Panax quinquefolium
thoracic aorta strip
potassium chloride cakium chlo-ride
norepinephrine
