摘要
采用ＭＴＴ法对肺癌细胞药物敏感性进行研究。先以ＭＴＴ与３Ｈ－ＴｄＲ掺入法分别测试８例肺癌原代细胞对４种抗癌药的反应并将两者加以比较，结果显示：两法有较好的相关性。后用ＭＴＴ法测试６种常用抗癌药对２０例原代肺癌细胞的作用，发现６种药物均有一定的抗癌作用，其中以卡铂（ＣＢＤＣＡ）作用最强。实验证实：ＭＴＴ法有较多优点，有一定临床实用价值。
The resistance of cancer cells to anti-cancer drugs is characterized by its complexity and changeability.The best way to design a chametheray for a cancer patient is to individualize the therapeutic scheme.The cell suspension of non-small cell lung cancer was cultured and the effects of 4 anti-cancer agents on the primary passage of 8 specimens of non-small cell lung cancer were correlated to those obtained with MTT.It was found that the results obtained with MTT were correlated to those obtained with 3 H-TdR incororation. Then 6 anti-cancer agents commonly employed in our daily practice were assessed on the primary passage of 20 specimens of non-small cell lung cancer and CBDCA was found to be the most powerful drug among the 6 and MTT was useful in the assessment of the sensitivity of cancer cells to anti-cancer agents.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1996年第2期125-128,共4页
Journal of Third Military Medical University
