摘要
目的观察黄芪注射液与卡托普利联合治疗早期糖尿病肾病的疗效。方法将69例早期糖尿病肾病患者随机分为3组(每组各23例),3组均在常规降糖治疗的基础上,A组加用卡托普利,B组加用卡托普利与黄芪注射液,C组加用黄芪注射液,疗程均为3个月,并观察治疗前后各组患者相关指标的变化。结果血压治疗后A、B组均比治疗前显著下降(P<0.01),C组治疗前后变化无显著性;血糖和糖化血红蛋白(HbA1c)治疗后B组和C组均比治疗前显著下降(P<0.05或P<0.01),B组与A组治疗后比较,差异有显著性(P<0.05);24h尿白蛋白排泄率和肾功能(BUN、SCr)3组治疗后均比治疗前显著下降(P<0.01),且B组下降幅度优于A和C组(P<0.05)。结论黄芪注射液与卡托普利联合治疗早期糖尿病肾病,在降低血压、血糖及HbA1c的同时,又可显著减少尿白蛋白的排出。
Objective To investigate the therapeutic effect of milkvetch injection （MI） combined with Captopril on early diabetic nephropathy （EDN）. Methods A total of 69 EDN patients were randomly divided into three groups, with 23 in each group. Besides the conventional hypoglycemic therapy, patients in Group A Captopril, in Group B MI plus Captopril and in Group C MI were given respectively. The therapeutic course for all was 3 months. The related indices of EDN before and after treatment were measured and compared, Results After treatment, the blood pressure significantly lowered after treatment in Group A and B（P 〈 0.01 ）, but unchanged in Group C; the levels of blood glucose and HbAlc significantly decreased in Group B and C（P 〈 0.05 or P〈0.01）, and significant difference was shown in comparison of Group B with Group A（P〈0.05） ; levels of 24hrs urinary albumin excretion （UAER）,blood urea nitrogen （BUN） and serum creatinine （SCr） significantly decreased in all 3 groups, and the decrement in Group B was more significant than that in the other two groups（P〈0.05）. Conclusion MI combined with Captopril can not only decrease blood pressure, blood glucose and HbAlc, but also significantly decrease the UAER in treating EDN.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2005年第11期993-995,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
黄芪注射液
卡托普利
联合治疗
早期糖尿病肾病
Milkvetch injection
Captopril
combined treatment
early diabetic nephropathy
