摘要
目的探讨M ICA基因第5外显子微卫星多态性与氯氮平诱发的白细胞减少症的关联性。方法应用聚合酶链反应和片段长度多态性分析,对93例健康对照者和72例氯氮平(或氯丙嗪)诱发白细胞减少者作M ICA基因第5外显子的多态性研究。结果(1)发现M ICA第5外显子的5种等位基因,并确定了在病例组和健康对照组中的分布频率。(2)表明M ICA第5外显子的A5和A5.1等位基因与精神药物诱发白细胞减少症有关联。(3)M ICA基因的等位基因和基因型分布在氯氮平诱发白细胞减少者与健康对照者之间无差异,但是在氯氮平诱发白细胞减少者与服非氯氮平者之间有显著差异。(4)氯氮平诱发白细胞减少与M ICA第5外显子的A5(OR=0.36,P<0.05,95%C I=0.86-0.15)和A5.1(OR=6.47,P<0.05,95%C I=31.50-1.33)相关联。结论M ICA基因的等位基因A5.1可能是氯氮平诱发白细胞减少症的风险因子,但是对于氯氮平不是专一的。
Objective： To investingate the association between polymorphism of major histocompatiblity complex class Ⅰ chain-related gene （MICA） exon 5 microsatellite and clozapine-induced leucopenia（CL）. Methods： The microsatellite polymprphism of MICA exon 5 in 93 unrelated healthy individuals and 72 cases of clozapine （or chloropromazine）-induced leucopenia were investingated using PCR-FLp analysis. Results： （1） Five alleles of exon5 in MICA gene were found in this study. The frequency of each allele was determined in patients and healthy individuals. （2） Allele A5 and A5.1 of exon 5 in MICA gene were associated with psychotropics-induced leucopenia. （3） No differences in allelic and genotypic distribution of MICA gene were observed between CL cases and herlthy individuals, but significant differente was observed between CL and non-CL. （4） CL were associated with A5 （OR=0.36,P〈0.05,95 % CI=0.86-0.15） and A5.1 （OR=6.47, P〈0.05,95% CI=31.50-1.33） in exon 5 of MICA gene. Conclusion： MICA gene-A5.1 polymorphism may be a risk factor for CL, but not especially for clozapine.
出处
《上海精神医学》
2005年第5期281-284,共4页
Shanghai Archives of Psychiatry
基金
上海市精神卫生中心课题基金
编号院2002-015
